Thursday, May 26, 2016

Researchers Discover Rare Human Disease in Dogs

By Veterinary Practice News Editors

Dr. Kurt Williams, associate professor of pathology and diagnostic investigation in Michigan State University's College of Veterinary Medicine, is lead author in a study discovering a rare, severe form of pulmonary hypertension in dogs.

"Researchers say they have discovered a rare, severe form of pulmonary hypertension in dogs that up until this point had only been classified as a human lung disease.

The study, which recently appeared in the journal Veterinary Pathology, involved researchers from Michigan State University College of Veterinary Medicine, University of California, Davis School of Veterinary Medicine, Cummings School of Veterinary Medicine at Tufts University and the University of London's Royal Veterinary College.

"Our research is the first to document the existence of pulmonary veno-occlusive disease, or PVOD, in dogs," said Kurt Williams, DVM, Ph.D., Dipl. ACVP, the lead author of the study and associate professor of pathology and diagnostic investigation in MSU's College of Veterinary Medicine. "PVOD is considered one of the most severe forms of pulmonary hypertension."

The number of pulmonary hypertension, or PH, cases reported in the United States is low, affecting 15 to 50 people per million each year, according to the researchers. PVOD is diagnosed in only about 10 percent of PH cases where no other cause of the disease has been determined. Unfortunately, the researchers noted, there are very few effective treatment options for PVOD and a lung transplant often becomes the best choice.

"PVOD might be more common in dogs than in people, but this has yet to be determined and needs to be looked at further," Dr. Williams said.

Pulmonary hypertension develops because of abnormal blood vessels in the lungs, which makes it harder for the heart to push blood through and provide oxygen to the rest of the body. In cases of PVOD, the small veins in the lungs became blocked, increasing pressure in these blood vessels, and ultimately causing heart failure, according to researchers.

"The same process happens in canines," Williams said.

The symptoms - cough, increased rate of breathing, respiratory distress, loss of appetite and chronic fatigue - are also similar, he said. However, "because subtle changes in health may not be recognized as quickly in dogs, death can occur quickly once the animal is seen by a veterinarian," he said.

"PVOD is a poorly understood disease not just because it's so rare, but also because there've been no other animals known to have the disease," Williams said. "Our finding changes things."

Williams said that the discovery could be important for human medicine because the canine disease may serve as a model for human PVOD.

"It's cases like this that help to remind us how important veterinary medicine is to medicine in general," he said. "Our colleagues in the human medical community are becoming much more aware of the many diseases shared by our respective patients and how together we can learn from each other."'

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